Journal: Frontiers in Immunology
Article Title: Improved Antitumor Activity of a Therapeutic Melanoma Vaccine through the Use of the Dual COX-2/5-LO Inhibitor Licofelone
doi: 10.3389/fimmu.2016.00537
Figure Lengend Snippet: Addition of licofelone to a long-peptide cancer vaccine therapy prolongs survival of melanoma-bearing mice . Groups of mice ( n = 7) were injected s.c. with 5 × 10 4 B16F10luc2 tumor cells and were subsequently left untreated or injected i.v. on day 6 with TRP2-peptide and α-GalCer in cationic liposomes or TRP2-peptide, α-GalCer, and licofelone in cationic liposomes. Mice that received a vaccine containing licofelone in cationic liposomes were also injected s.c. every second day with the licofelone formulated into cationic liposomes while a control group of mice received only s.c. injections of licofelone liposomes. The graph shows the Kaplan–Meier survival curve. Data are representative of two independent experiments with each n = 7 mice/group, *** p < 0.0001.
Article Snippet: B16F10luc2 melanoma cells were obtained from ATCC, New Zealand.
Techniques: Injection, Liposomes, Control